How to use a specific axd file instead the default axd file created by asp.net?

How to use a specific axd file instead the default axd file created by
asp.net?

I use some Telerik controls in my web site (on .net 4 server) - they do
not work good in some web browsers. One day, I find they can work good on
.net 4.5 server.
I notice the .axd files (Telerik.Web.UI.WebResource.axd) created by .net 4
and 4.5 are different. So I want to change .axd file setting in
web.config:
<add path="Telerik.Web.UI.WebResource.axd"
type="Telerik.Web.UI.WebResource" verb="*" validate="false"/>
But I am not sure whether this is available and how to change the setting.